LOI 2020 Ryerson University Letter of Intent Paper

Question Description

-goal of letter of intent is to develop a treatment for methanol poisoning

-must answer 4 sections

1. Background: essential info of enzyme, 1ADC (this is the type of alcohol dehydrogenase that is studied for this LOI). section must include mechanism of the 1ADC, such as active sites, structures, substrates/inhibitors.

2. rationale; provide a persuasive explanation of the problem/challenge (related to alcohol poisoning)that is the focus of your LOI

3. specific research goal and objective: provide a short description of the key experiments that you will propose to conductto achieve that objective

4.significance of the LOI proposed research: provide a short statement of the relevance and significance of your proposedresearch and how it will contribute to a solution to the problem identified in the rationale

-more detail for instructions will be in file named “LOI intstructions”, I have also provided a sample LOI

-Must include an image of enzyme from proteopedia

-info of ADC will be PDB (protein databank)

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