University of North Carolina at Charlotte Transgenerational Epigenetic Paper

Question Description

Article Review

100 points

On Blackboard, the following article has been posted:

van Otterdijk, S.D., and Michels, K.B. (2016). Transgenerational epigenetic inheritance in mammals: how good is the evidence? FASEB Journal, (30), p. 2457-2465.

This is a review article that summarizes a number of research studies related to epigenetic inheritance. Please refer to the section on epigenetic inheritance in your textbook on page 217.

For the questions below, please refer to the appropriate sections of the article as indicated in order to answer each question.

Please type your answers on a separate file. Do not put your answers in the spaces below. Submit the answers to the questions in Blackboard as a file upload.

(20 points) Using information provided on pages 2457-2458, discuss:
1. what epigenetics is and why it is thought to be important
2. what are the primary mechanisms involved in epigenetic inheritance
3. what sorts of cellular changes may occur as a result of epigenetics
(20 points) Referring to page 2458, discuss how epigenetics might have evolutionary influences.
(20 points) Also on page 2458, there is a discussion of intrauterine exposures and how that might affect the fetuss phenotype. What are some known exposures that affect the fetus in this way?
(20 points) Referring to page 2459, discuss how/why genomic imprinting may be the strongest evidence for transgenerational epigenetic inheritance.
(10 points) On pages 2462-2463, summarize the main points of the authors discussion and conclusions. Does transgenerational epigenetic inheritance exist? What might be some limitations of studying this in humans?
(10 points) Using the RMU Library database system, find a primary literature article that is related to this topic. Provide the full citation for this article as the answer to this question.

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